Paul-Martini-Stiftung / Preisträger vor 2011

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization (Nature Immunology 2008)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC (Nature 2009) RIG-I-dependent sensing of Poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate (Nature Immunology 2009)
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin-1ß production (Nature Immunology 2010)

Adjuvanticity of a synthetic cord factoranalogue for subunit Mycobacterium tuberculosis vaccination requires FcRy-Syk–Card9–dependent innate immune activation (Journal of Experimental Medicine 2009)
Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells (Journal of Experimental Medicine 2009)
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence (Nature 2009) Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin- 1ß production (Nature Immunology 2010)

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody

1. Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis
2. Epidemiology of Sepsis in Germany: Results from a National Prospective Multicenter Study

MIF is a noncognate ligand for CXC chemokine receptors in inflammatory and atherogenic cell recruitment

1. LSD1 demethylates repressive histone marks to promote androgen receptor dependent transcription
2. Co-operative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
3. Androgen receptor coactivators LSD1 and FHL2 predict risk of prostate cancer recurrence

1. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene
2. Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferae haplotype

1. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
2. HDL stimulates myocardial perfusion in vivo
3. The immunosuppressant FTY720 induces eNOS-dependent arterial vasodilation via the lysophospholipid receptor S1P3
4. High-density lipoproteins and their constituent sphingosine-1-phosphate directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 sphingolipid receptor

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

1. Oral Sildenafil as Long-Term Adjunct Therapy to Inhaled Iloprost in Severe Pulmonary Arterial Hypertension
2. Sildenafil for Long-Term Treatment of Nonoperable Chronic Thromboembolic Pulmonary Hypertension
3. Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension
4. Sildenafil for treatment of lung fibrosis und pulmonary hypertension: a randomised controlled trial

1. High plasma basic fibroblast growth factor concentration is associated with response to thalidomide in progressive multiple myeloma
2. Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
3.Polymorphisms of the tumor necrosis factor-alpha gene promotor predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma
4. Dose-dependent effect of thalodomide on overall survival in relapsed multiple myeloma

1. Neuroprotection Mediated by Changes in The Endothelial Actin Cytoskeleton
2. Withdrawal of Statins Increases Event Rates in Patients With Acute Coronary Syndroms
3. Supression of Endothelial Nitric Oxide Production After Withdrawal of Statin Treatment Is Mediated by Negative Feedback Regulation of Rho GTPase Gene Transcription
4. Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice

1. Resistance of PH+ acute lymphoblastic leukemia to the tyrosine kinase inhibitor STI571 (Glivec ^TM) is associated with distinct gene expression profiles implicating diverse mechanisms of resistance
2. Ph+ acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 (Glivec ^TM) has a unique BCR-ABL gene mutation

1. Inhibition of P-glycoprotein mediated drug transport: A Unifying mechanism to explain the interaction between digoxin and quinidine
2. Bedeutung des intestinalen Stoffwechsels und des ABC-Transporterproteins G-Glykoprotein für die Pharmakokinetik und Wirkung von Arzneimitteln

Untersuchungen zur Biologie antimikrobieller Peptide und deren Verwendbarkeit als Pharmaka

Delineation of a CpG Phosporothioate Oligodesooxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

1. L-Arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia
2. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
3. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease

Klinik, Diagnostik, Pathophysiologie und Therapie der Heparin-induzierten Thrombozytopenie

1. A Short-Term Trial of Tacrolimus Ointment For Atopic Dermatitis
2. Antioncogene P53 and Mitogenic Cytokine Interleukin-8 Aberrantly Expressed in Psoriatic Skin Are Inversely Regulated by the Antipsoriatic Drug Tacrolimus (FK506)
3. FK506 in the treatment of inflammatory skin disease: promises and perspectives
4. Topical FK506 Suppresses Cytokine and Co-stimulatory Molecule expression in Epidermal and Local Draining Lymph node Cells during Primary Skin Immune Responses

Novel therapeutic strategies via the apoptosis pathways to resolve chronic eosinophilic inflammation

Die Lokalisationsabhängigkeit der Arzneistoffresorption im Dünndarm des Menschen

New Insight into Mechanisms Underlying the Phenomenon of Nitrate Tolerance

Retinoids: Novel, Experimental Strategy for the Treatment of Human Pancreatic Adenocarcinoma

Untersuchung zur Bedeutung von Th2-Lymphozyten und ihre Rolle bei der Aktivierung von eosynophilen Granulozyten am Modell der endobronchialen Allergenprovokation von Asthmatikern

Bile Excretory Pathways

Ara-C: Synergismus mit Zytokinen und molekulare Wirkungsmechanismen

Endopeptidase-Inhibition

Untersuchung zur Vorhersage der Variabilität des Arzneimittelnetabolismus in vivo aus in vitro Experimenten und der Konsequenzen für die Arzneimittelwirkung am Beispiel von Propafenon und Verapamil

In vivo - in vitro Korrelation der Arzneistofffreisetzung

1. Increased nonrenal clearance and increased diuretic efficiency of furosemide in cystic fibrosis
2. Diuretic effect and diuretic efficiency after intravenous dosage of furosemide
3. Reversible hearing impairment related to quinine blood concentration in guinea pigs

Klinischer Nachweis von Immunodulation durch Lektine im Rahmen der Misteltherapie

Low-dose Interleukin-2 induces systemic responses against HbsAG in immunodeficient non-responders to hepatitis B vaccination

Hypnotic Treshold Concentrations of Methohexitone and Closed-Loop Feedback Control of Methohexital Anaesthesia by Quantitative EEG Analysis in Humans

Kevin J. Scanlon (Duarte (CA) USA)

Biochemical basis for cisplatin an 5-flourouracil synergism in human ovarian carcinoma cells

Dynamic Analysis of Endsystolic Pressure/ Volume Relationships during Therapeutic Interventions

Zur spinalen Infusion von Opiaten und Somatostasin

(-)-Adrenaline-induced, calcium-dependent phosphorylation in human platelets: increase in essential hypertension, inhibition by Verapamil

Quantitative Bestimmung adrenerger alpha- und beta-Rezeptoren des Menschen: Eine Methode zur genauen Beurteilung klinisch-pharmakologischer und therapeutischer Maßnahmen

Humanpharmakologische Untersuchung zur Wirksamkeit von Ulkustherapeutika

Pharmacogenetics of mephenytoin: A new drug hydroxilation polymorphism in man 'Ductus Arteriosus'

Chinidin-Digoxin: Pharmakokinetik und Pharmakodynamik einer exemplarischen Arzneimittelinteraktion

Multivariate Prognosemodelle in der Medizin

Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' tissues during glycoside therapy.

Secondary Prevention of Myocardial Infarction, a Comparison of Acetylsalicylic Acid, Placebo and Phenprocoumon

Adenylate Cyclase in Human Gastric Mucosa

Immunological Detection and Monitoring of Leukaemic Cells

Ein neuentdeckter Defekt im Arzneimittelstoffwechsel des Menschen: Die fehlende N-Oxydation des Spartein

Dynamik, Koronardurchblutung und Sauerstoffverbrauch des normalen und kranken Herzens

Elimination Kinetics and Dosage Adjustment of Chemotherapeutic Agents in Patients with Kidney Diseases

A Study of the Pharmacokinetics of Phenytoin (Diphenylhydantoin) in Epileptic Patients and the Development of a Practical Scheme for Making Dose Increments

Pharmacokinetics, Pharmacodynamics and Interaction of Warfarin

Evaluation of Hormone Dependence of Breast Cancer for the Individual Patient

Determination of Drug Metabolizing Enzymes in Needle Biopsies of Human Liver

Über die Veränderung des Abbaus von Arzneimitteln unter verschiedenen Bedingungen. Klinische und tierexperimentelle Untersuchungen

Experimental Basis of the Diagnosis and Oral Therapy of Prelatent, Latent and Manifest Iron Deficiency

Statistical Logic in the Monitoring of Reactions to Therapeutic Drugs

Pharmakokinetische Methoden zur Ermittlung der enteralen Resorption

Methodogical Problems of Prophylactic Trials in Recurrent Affective Disorders

Messung der Asorption des Fingerknochens mit einem 125 J-Scanner

Studies of the Metabolism of Guanethidine in Hypersensitive Patients